Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Sco2tm1.1Easc
Name:	SCO2 cytochrome c oxidase assembly protein; targeted mutation 1.1, Eric A Schon
MGI ID:	MGI:4413584
Synonyms:	Sco2loxPKO
Gene:	Sco2  Location: Chr15:89255840-89258049 bp, - strand  Genetic Position: Chr15, 44.85 cM
Alliance:	Sco2tm1.1Easc page

Germline Transmission:	Earliest citation of germline transmission: J:155116
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A floxed neo cassette was inserted 30 bp downstream of the translation initiation site. Cre mediated recombination removed the neo cassette leaving a single loxP site. The absence of COX activity was confirmed in E8.5 embryos. (J:155116)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sco2 Mutation:	4 strains or lines available

Original:	J:155116 Yang H, et al., Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2. Hum Mol Genet. 2010 Jan 1;19(1):170-80
All:	6 reference(s)