Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dicer1tm1.1Mmk
Name:	dicer 1, ribonuclease type III; targeted mutation 1.1, Matthias Merkenschlager
MGI ID:	MGI:3795355
Synonyms:	dcrdelta
Gene:	Dicer1  Location: Chr12:104654001-104718211 bp, - strand  Genetic Position: Chr12, 54.83 cM, cytoband E-F1
Alliance:	Dicer1tm1.1Mmk page

Germline Transmission:	Earliest citation of germline transmission: J:135783
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 20 and 21, which contain the RNaseII domain, were removed by germ line, cre-mediated recombination. No functional protein product is expected to be produced. (J:135783)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dicer1 Mutation:	94 strains or lines available

Original:	J:135783 Koralov SB, et al., Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell. 2008 Mar 7;132(5):860-74
All:	1 reference(s)