Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Thbdtm2Wlr Name: thrombomodulin; targeted mutation 2, Harmut Weiler MGI ID: MGI:2158819 Synonyms: TMLox Gene: Thbd  Location: Chr2:148246391-148250108 bp, - strand  Genetic Position: Chr2, 73.45 cM Alliance: Thbdtm2Wlr page

Cardiomegaly in Thbdtm2Rdr/Thbdtm2Wlr Tg(Tek-cre)1Ywa/0 mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:71269
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted that flank the coding regions of the gene as well as an introduced neomycin selection cassette. These insertions have no effect on the normal function of the gene. (J:71269)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thbd Mutation:	23 strains or lines available

Original:	J:71269 Isermann B, et al., Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis. J Clin Invest. 2001 Aug;108(4):537-46
All:	7 reference(s)