Thbdtm2Rdr
Targeted Allele Detail
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| Symbol: |
Thbdtm2Rdr |
| Name: |
thrombomodulin; targeted mutation 2, Robert D Rosenberg |
| MGI ID: |
MGI:2158818 |
| Synonyms: |
Thbd-, TMlacZ, TMlacZ, TM-lacZ |
| Gene: |
Thbd Location: Chr2:148246391-148250108 bp, - strand Genetic Position: Chr2, 73.45 cM
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| Alliance: |
Thbdtm2Rdr page
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Venous and arterial thrombi and extravascular fibrinogen deposition in the lungs of Thbdtm2Rdr/Thbdtm2Wlr Tg(Tek-cre)1Ywa/0 mice
Show the 3 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:74855
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| Parent Cell Line: |
D3 (ES Cell)
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| Strain of Origin: |
129S2/SvPas
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutation: |
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Insertion
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Mutation details: A lacZ gene and neomycin selection cassette was inserted into the start codon of the gene. A hybrid mRNA molecule, consisting of 157 nucleotides of the endogenous 5' untranslated mRNA followed by the lacZ open reading frame, was transcribed from this allele.
(J:71269, J:74855)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Thbd Mutation: |
23 strains or lines available
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| Original: |
J:74855 Weiler-Guettler H, et al., Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus. Circ Res. 1996 Feb;78(2):180-7 |
| All: |
12 reference(s) |
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Analysis Tools
