Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Esr1tm1Geog
Name:	estrogen receptor 1 (alpha); targeted mutation 1, Geoffrey Greene
MGI ID:	MGI:3795228
Synonyms:	ENERKI, ERalphaG525L
Gene:	Esr1  Location: Chr10:4561989-4955633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Alliance:	Esr1tm1Geog page

Germline Transmission:	Earliest citation of germline transmission: J:135981
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Not Applicable) Mutation:    Insertion   Mutation details: Exon 9 was replaced with a self-excising floxed neo cassette and an exon 9 containing a nucleotide susbtitution that results in an amino acid substitution of leucine for glycine at position 525 (G525L). (J:135981)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:	67 strains or lines available

Original:	J:135981 Sinkevicius KW, et al., An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo. Endocrinology. 2008 Jun;149(6):2970-9
All:	4 reference(s)