Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppargtm1.1Unc
Name:	peroxisome proliferator activated receptor gamma; targeted mutation 1.1, University of North Carolina
MGI ID:	MGI:4412008
Gene:	Pparg  Location: Chr6:115337912-115467360 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Alliance:	Ppargtm1.1Unc page

Germline Transmission:	Earliest citation of germline transmission: J:154767
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mutation details: A 345 bp fragment containing the 3' UTR was replaced with an 855bp fragment containing the rabbit beta-globin 3' UTR and a self-excising neo cassette via homologous recombination. The self-excising neo resistance cassette was then removed during germline transmission. Quantitative RT-PCR showed that the steady-state message levels were increased in adipose tissue, kidneys, liver and heart in homozygous and heterozygous mice compared to wild-type littermates. Real-time RT-PCR indicated that the transcripts from the knock-in allele were more stable than those from the wild-type allele. (J:154767)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:	39 strains or lines available

Original:	J:154767 Tsai YS, et al., Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19084-9
All:	2 reference(s)