Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Efemp2tm1.2Tynk
Name:	epidermal growth factor-containing fibulin-like extracellular matrix protein 2; targeted mutation 1.2, Tomoyuki Nakamura
MGI ID:	MGI:4410302
Synonyms:	Fbln4deltaEx2
Gene:	Efemp2  Location: Chr19:5523982-5532545 bp, + strand  Genetic Position: Chr19, 4.33 cM, cytoband A
Alliance:	Efemp2tm1.2Tynk page

Germline Transmission:	Earliest citation of germline transmission: J:154659
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Germ line, cre mediated recombination removes exon 2. The absence of protein expression was confirmed by western blot analysis on lung extracts. (J:154659)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Efemp2 Mutation:	26 strains or lines available

Original:	J:154659 Horiguchi M, et al., Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19029-34
All:	1 reference(s)