Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppargtm1Laz
Name:	peroxisome proliferator activated receptor gamma; targeted mutation 1, Mitchell A Lazar
MGI ID:	MGI:3794857
Synonyms:	PPARgamma-S112A
Gene:	Pparg  Location: Chr6:115337912-115467360 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Alliance:	Ppargtm1Laz page

Germline Transmission:	Earliest citation of germline transmission: J:135904
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Exon 2 was replaced with an exon 2 containing a nucleotide substitution that resulted in the amino acid substitution of alanine for serine at position 112 (S112A). A floxed neo cassette downstream of the modified exon 2 used for selection purposes was removed by cre-mediated recombination in ES cells. This mutant version of PPARgamma is nonphosphorylatable and has more biological activity. (J:135904)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:	39 strains or lines available

Original:	J:135904 Rangwala SM, et al., Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity. Dev Cell. 2003 Oct;5(4):657-63
All:	4 reference(s)