Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Zap70tm2.1Weis
Name:	zeta-chain (TCR) associated protein kinase; targeted mutation 2.1, Arthur Weiss
MGI ID:	MGI:4399123
Synonyms:	YYAA
Gene:	Zap70  Location: Chr1:36800879-36821899 bp, + strand  Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
Alliance:	Zap70tm2.1Weis page

Germline Transmission:	Earliest citation of germline transmission: J:154166
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted Mutation:    Nucleotide substitutions   Mutation details: Residues Y315 and Y319 present in exon 7 of ZAP-70 were mutated to alanine. A diagnostic EcoRV site was also introduced into exon 7 as well as a floxed neo cassette in intron 2. Cre mediated recombination in the male germline subsequently removed the neo cassette. (J:154166)

Generation of the Zap70tm2.1Weis allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zap70 Mutation:	55 strains or lines available

Original:	J:154166 Hsu LY, et al., A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. J Exp Med. 2009 Oct 26;206(11):2527-41
All:	2 reference(s)