Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Timp3tm1Osya
Name:	tissue inhibitor of metalloproteinase 3; targeted mutation 1, Osamu Yasuda
MGI ID:	MGI:4398972
Gene:	Timp3  Location: Chr10:86136276-86185369 bp, + strand  Genetic Position: Chr10, 42.83 cM, cytoband C1-D1
Alliance:	Timp3tm1Osya page

Germline Transmission:	Earliest citation of germline transmission: J:154849
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot analysis on kidney extracts. (J:154849)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Timp3 Mutation:	18 strains or lines available

Original:	J:154849 Kawamoto H, et al., Tissue inhibitor of metalloproteinase-3 plays important roles in the kidney following unilateral ureteral obstruction. Hypertens Res. 2006 Apr;29(4):285-94
All:	13 reference(s)