Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm2(CMV-Bmi1,EGFP)Nki
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 2, The Netherlands Cancer Institute
MGI ID:	MGI:4398914
Synonyms:	Bmi1Lox66/Lox71, Bmi-CTI
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm2(CMV-Bmi1,EGFP)Nki page

Germline Transmission:	Earliest citation of germline transmission: J:187257
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The targeting construct contains a CMV promoter followed by a LoxP66 site, a cDNA encoding an antisense mouse Bmi1, an IRES, an eGFP cassette and a LoxP71 followed by a PGK promoter neo cassette. Cre expression enables the inversion of the antisense Bmi1. (J:187257)

Schematic of the Gt(ROSA)26Sortm2(CMV-Bmi1,EGFP)Nki allele

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:187257 Westerman BA, et al., GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors. PLoS One. 2012;7(5):e35943
All:	1 reference(s)