Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pdcd1tm1.1Shr
Name:	programmed cell death 1; targeted mutation 1.1, Arlene H Sharpe
MGI ID:	MGI:4397682
Synonyms:	PD-1-
Gene:	Pdcd1  Location: Chr1:93966027-93980278 bp, - strand  Genetic Position: Chr1, 47.47 cM
Alliance:	Pdcd1tm1.1Shr page

Germline Transmission:	Earliest citation of germline transmission: J:153040
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neo cassette was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 3. Transient cre expression in ES cells removed exons 2 and 3 along with the neo cassette. (J:153040)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

5 assay results 1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Pdcd1 Mutation:	97 strains or lines available

Original:	J:153040 Keir ME, et al., PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues. J Immunol. 2007 Oct 15;179(8):5064-70
All:	58 reference(s)