Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	E2f6tm1Lees
Name:	E2F transcription factor 6; targeted mutation 1, Jacqueline A Lees
MGI ID:	MGI:3790807
Gene:	E2f6  Location: Chr12:16860932-16876753 bp, + strand  Genetic Position: Chr12, 8.04 cM
Alliance:	E2f6tm1Lees page

Germline Transmission:	Earliest citation of germline transmission: J:134271
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4 through 8, encoding the DNA binding, leucine zipper, and marked box domains were replaced via homologous recombination with a floxed PGK-neo cassette that includes a stop codon at the beginning. Western blot analysis of homozygous MEFs confirmed the absence of protein expression. (J:134271)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	27 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any E2f6 Mutation:	12 strains or lines available

Original:	J:134271 Courel M, et al., E2f6 and Bmi1 cooperate in axial skeletal development. Dev Dyn. 2008 May;237(5):1232-42
All:	2 reference(s)