Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(CAG-Foxo1*)Jcbr
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jens C Bruning
MGI ID:	MGI:3790725
Synonyms:	FOXO1delta256
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(CAG-Foxo1*)Jcbr page

Germline Transmission:	Earliest citation of germline transmission: J:134336
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A transgene containing a Foxo1 cDNA with a truncation at amino acid position 256 followed by an IRES-GFP and driven by the CAGGS promoter (chicken beta actin promoter with CMV enhancers) was inserted into intron 1. An interviening floxed neo-STOP cassette prevents expression of the truncated Foxo1 cDNA except in the presence of cre when the floxed neo-STOP cassette is excised. (J:134336)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:134336 Belgardt BF, et al., PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response. Cell Metab. 2008 Apr;7(4):291-301
All:	2 reference(s)