Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gad1tm1(Gria2)Mony
Name:	glutamate decarboxylase 1; targeted mutation 1, Hannah Monyer
MGI ID:	MGI:3785546
Synonyms:	GAD-GluR-B
Gene:	Gad1  Location: Chr2:70391644-70432358 bp, + strand  Genetic Position: Chr2, 41.63 cM, cytoband D
Alliance:	Gad1tm1(Gria2)Mony page

Germline Transmission:	Earliest citation of germline transmission: J:134013
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inserted expressed sequence, Reporter) Mutation:    Insertion   Mutation details: A cassette containing rat cDNA for Gria2 with with 200 bp of the 5' untranslated region and the Q/R site edited in the flip configuration, an IRES, a lacZ reporter gene and a neo selection marker was knocked into exon 2 upstream of the translation initiation codon. Gria2 expression is detected in GABAergic interneurons by immunocytohistochemistry. This is a reporter and knockin allele. (J:134013)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gad1 Mutation:	64 strains or lines available

Original:	J:134013 Fuchs EC, et al., Genetically altered AMPA-type glutamate receptor kinetics in interneurons disrupt long-range synchrony of gamma oscillation. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3571-6
All:	1 reference(s)