Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slco1b2tm1Cdk
Name:	solute carrier organic anion transporter family, member 1b2; targeted mutation 1, Curtis D Klaassen
MGI ID:	MGI:3785252
Gene:	Slco1b2  Location: Chr6:141575244-141632372 bp, + strand  Genetic Position: Chr6, 72.57 cM, cytoband G1
Alliance:	Slco1b2tm1Cdk page

Germline Transmission:	Earliest citation of germline transmission: J:133919
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 3 was disrupted by insertion of a floxed neo cassette. Low levels of a truncated mRNA transcript are detected. Western blot analysis confirmed the absence of protein in homozygous livers. Therefore, this is a null allele. (J:133919)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slco1b2 Mutation:	47 strains or lines available

Original:	J:133919 Lu H, et al., Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol Sci. 2008 May;103(1):35-45
All:	1 reference(s)