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Dot1lGt(RRR032)Byg
Gene trapped Allele Detail
Summary
Symbol: Dot1lGt(RRR032)Byg
Name: DOT1 like histone lysine methyltransferase; gene trap RRR032, BayGenomics
MGI ID: MGI:3784999
Synonyms: Dot1L KO
Gene: Dot1l  Location: Chr10:80591040-80631295 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Dot1lGt(RRR032)Byg page
Mutation
origin
Mutant Cell Line:  RRR032
Germline Transmission:  Earliest citation of germline transmission: J:133922
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0Lxf     Vector Type: gene trap
    A gene trap vector was inserted into intron 12. (J:133922)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dot1l Mutation:  69 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:133922 Steger DJ, et al., DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol. 2008 Apr;28(8):2825-39
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory