Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chn1Gt714Lex
Name:	chimerin 1; gene trap 714, Lexicon Genetics
MGI ID:	MGI:3783264
Synonyms:	alpha-2-, alpha2gt
Gene:	Chn1  Location: Chr2:73441004-73605690 bp, - strand  Genetic Position: Chr2, 43.78 cM
Alliance:	Chn1Gt714Lex page

Germline Transmission:	Earliest citation of germline transmission: J:128698
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Gene trapped (Hypomorph) Mutation:    Insertion of gene trap vector   Mutation details: A beta-geo gene trap vector was inserted upstream of the promoter region for the alpha-1 N-terminally truncated isoform in the middle of the locus. Western blot analysis confirmed the absence of protein in the spinal cord and a reduction of protein production in brain extracts of homozygotes. (J:128698)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chn1 Mutation:	44 strains or lines available

Original:	J:128698 Beg AA, et al., alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits. Neuron. 2007 Sep 6;55(5):768-78
All:	4 reference(s)