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Gt(ROSA)26Sortm1(cre/ERT2)Alj
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(cre/ERT2)Alj
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Alexandra L Joyner
MGI ID: MGI:3778915
Synonyms: Gt(ROSA)26Sortm1(cre/ESR1)Alj, Rosa26CreERT2, Rosa26CreERT2, Rosa26CreERT2neo
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(cre/ERT2)Alj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:133568
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(cre/ERT2)Alj expression driven by 1 gene
 
Mutation detailsA Cre/ERT2 fusion and frt flanked neo cassette were inserted into the Rosa26 locus by homologous recombination. The neo cassette was removed by Flpe mediated recombination. (J:156169)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gt(ROSA)26Sor (mouse)
Summary of all recombinase alleles driven by Gt(ROSA)26Sor.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm1(cre/ERT2)Alj
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  942 strains or lines available
References
Original:  J:133568 Takeda K, et al., Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation. 2007 Aug 14;116(7):774-81
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory