Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cyp11a1tm2Bcc
Name:	cytochrome P450, family 11, subfamily a, polypeptide 1; targeted mutation 2, Bon-Chu Chung
MGI ID:	MGI:3778793
Synonyms:	Cyp11a1L
Gene:	Cyp11a1  Location: Chr9:57913694-57934306 bp, + strand  Genetic Position: Chr9, 31.63 cM
Alliance:	Cyp11a1tm2Bcc page

Germline Transmission:	Earliest citation of germline transmission: J:133007
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted Mutations:    Insertion, Nucleotide substitutions   Mutation details: The proximal SF-1 binding site in intron 1 was replaced with one in which the genetic sequence was altered from TAGCCTTGA to TAGaaTTGA. A floxed neo cassette with a 3' lox P site was inserted in intron 1 but was removed by germ-line, cre-mediated recombination. Expression of the protein product was reduced 7-fold in the adrenal and testis but was unaffected in the placenta and ovary. (J:133007)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cyp11a1 Mutation:	41 strains or lines available

Original:	J:133007 Shih MC, et al., Mutation of Mouse Cyp11a1 Promoter Caused Tissue-Specific Reduction of Gene Expression and Blunted Stress Response without Affecting Reproduction. Mol Endocrinol. 2008 Apr;22(4):915-23
All:	1 reference(s)