Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Sh3tc2tm1.1Rchr
Name:	SH3 domain and tetratricopeptide repeats 2; targeted mutation 1.1, Roman Chrast
MGI ID:	MGI:4367025
Synonyms:	Sh3tc2deltaEx1
Gene:	Sh3tc2  Location: Chr18:62086002-62148790 bp, + strand  Genetic Position: Chr18, 34.78 cM
Alliance:	Sh3tc2tm1.1Rchr page

Germline Transmission:	Earliest citation of germline transmission: J:153705
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with EGFP and a floxed neo cassette. Germ line, cre mediated recombination removes the neo cassette. (J:153705)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sh3tc2 Mutation:	61 strains or lines available

Original:	J:153705 Arnaud E, et al., SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17528-33
All:	3 reference(s)