Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Traf3tm1.1Rbr
Name:	TNF receptor-associated factor 3; targeted mutation 1.1, Robert Brink
MGI ID:	MGI:3777325
Synonyms:	Traf3delta
Gene:	Traf3  Location: Chr12:111132804-111233587 bp, + strand  Genetic Position: Chr12, 60.94 cM, cytoband F
Alliance:	Traf3tm1.1Rbr page

Germline Transmission:	Earliest citation of germline transmission: J:132877
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Germline deletion of the gene locus was achieved by crossing Traf3tm1Rbr mice with Tg(Zp3-cre)3Mrt mice that express Cre in oocytes. Genomic PCR confirmed deletion of exon 4 in the gene locus. (J:132877)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf3 Mutation:	42 strains or lines available

Original:	J:132877 Gardam S, et al., TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity. 2008 Mar;28(3):391-401
All:	1 reference(s)