Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Traf3tm1Rbr
Name:	TNF receptor-associated factor 3; targeted mutation 1, Robert Brink
MGI ID:	MGI:3777324
Synonyms:	Traf3lox
Gene:	Traf3  Location: Chr12:111132804-111233587 bp, + strand  Genetic Position: Chr12, 60.94 cM, cytoband F
Alliance:	Traf3tm1Rbr page

Germline Transmission:	Earliest citation of germline transmission: J:132877
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted around exon 4 of the gene locus and a FRT-flanked neomycin resistance cassette was placed further downstream in intron 4. Chimeric mice were mated with Flp expressing transgenic mice to remove the neomycin cassette. Gene expression was unaffected as determined by immunoblot analysis of lymphoid tissue from homozygotes. Crossing this strain with a strain expressing Cre will lead to deletion of exon 4 and cause a frameshift mutation in the gene locus. (J:132877)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf3 Mutation:	42 strains or lines available

Original:	J:132877 Gardam S, et al., TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity. 2008 Mar;28(3):391-401
All:	12 reference(s)