Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Runx1tm2Itan
Name:	runt related transcription factor 1; targeted mutation 2, Ichiro Taniuchi
MGI ID:	MGI:3777251
Synonyms:	Runx1PM13A, Runx1S249/276A
Gene:	Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance:	Runx1tm2Itan page

Germline Transmission:	Earliest citation of germline transmission: J:132661
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Hypomorph) Mutation:    Nucleotide substitutions   Mutation details: An exoncarrying a nucleotide substitution that resulted in an amino acid substitution of serine to alanine at position 249 and 276 (S249A, S276A) and a floxed neo cassette were knocked into the open reading frame. The neo cassette was removed by transient cre expression. (J:132661)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:	35 strains or lines available

Original:	J:132661 Tachibana M, et al., Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation. Biochem Biophys Res Commun. 2008 Apr 11;368(3):536-42
All:	1 reference(s)