Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	H2-Aab-tm1Blt
Name:	histocompatibility 2, class II antigen A, alpha; targeted mutation 1, Horst Bluethmann
MGI ID:	MGI:2157977
Synonyms:	Aa0, Aalpha-, H2-Aatm1Blt, MHC class II-
Gene:	H2-Aa  Location: Chr17:34501718-34506797 bp, - strand  Genetic Position: Chr17, 17.98 cM
Alliance:	H2-Aab-tm1Blt page

Germline Transmission:	Earliest citation of germline transmission: J:16372
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a PGK-neomycin resistance cassette into exon 2, which encodes the alpha-1 domain of the A-alpha chain, disrupted the gene. Cytofluorometric analyses of lymphocytes from thymus and lymph nodes did not detect expression of the A-alphaA-beta heterodimer in homozygous mutant mice. (J:16372)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any H2-Aa Mutation:	30 strains or lines available

Original:	J:16372 Kontgen F, et al., Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. Int Immunol. 1993 Aug;5(8):957-64
All:	45 reference(s)