Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mmp17tm1Ski
Name:	matrix metallopeptidase 17; targeted mutation 1, Motoharu Seiki
MGI ID:	MGI:3777020
Synonyms:	Mt4-mmp-, Mt4-mmpLacZ
Gene:	Mmp17  Location: Chr5:129661233-129688163 bp, + strand  Genetic Position: Chr5, 68.18 cM
Alliance:	Mmp17tm1Ski page

Germline Transmission:	Earliest citation of germline transmission: J:132553
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A lacZ cassette with a nuclear localization sequence and a PGK-gpt/neo cassette were inserted after the translation initiation site in the first exon and replaced part of the first exon through the first intron. The absence of endogenous transcript expression and the presence of a lacZ transcript was confirmed by RT-PCR on brain extracts. This is a null allele. (J:132553)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	104036 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp17 Mutation:	34 strains or lines available

Original:	J:132553 Rikimaru A, et al., Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using beta-galactosidase. Genes Cells. 2007 Sep;12(9):1091-100
All:	6 reference(s)