Lrrk2tm1(KOMP)Wtsi
Targeted Allele Detail
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| Symbol: |
Lrrk2tm1(KOMP)Wtsi |
| Name: |
leucine-rich repeat kinase 2; targeted mutation 1, Wellcome Trust Sanger Institute |
| MGI ID: |
MGI:4363891 |
| Gene: |
Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
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| IMPC: |
Lrrk2 gene page |
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| Mutant Cell Line: |
EPD0330_1_C02 |
| Germline Transmission: |
Unknown
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| Parent Cell Line: |
JM8A1.N3 (ES Cell)
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| Strain of Origin: |
C57BL/6N-Atm1Brd
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| Project Collection: |
KOMP-CSD
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 3642 starting at position 91593461 and ending at position 91597103 of Chromosome 15 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site.
(J:148605, J:173534)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Lrrk2 Mutation: |
156 strains or lines available
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| Original: |
J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009; |
| All: |
2 reference(s) |
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Analysis Tools
