Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ldhaa-m12Neu
Name:	lactate dehydrogenase A; mutation 12, Neuherberg
MGI ID:	MGI:3776296
Synonyms:	LDH 144, Ldh1a12Neu
Gene:	Ldha  Location: Chr7:46491698-46505051 bp, + strand  Genetic Position: Chr7, 30.6 cM
Alliance:	Ldhaa-m12Neu page

Strain of Origin:

C3H/El

Allele Type:    Radiation induced Mutation:    Single point mutation   Mutation details: Gamme radiation-induced mutagenesis resulted in a transition in codon 241 (ATC to ACC) that caused an amino acid substitution of threonine for isoleucine at position 241 (I241T). Enzyme activity is reduced to 59% of wild-type in heterozygotes and 29% of wild-type in homozygotes. (J:45877)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ldha Mutation:	34 strains or lines available

Original:	J:45877 Pretsch W, et al., Molecular, genetic and biochemical characterization of lactate dehydrogenase-A enzyme activity mutations in Mus musculus. Mamm Genome. 1998 Feb;9(2):144-9
All:	1 reference(s)