Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ldhaa-m7Neu
Name:	lactate dehydrogenase A; mutation 7, Neuherberg
MGI ID:	MGI:3776295
Synonyms:	Ldh17Neu, LDH 1962, Ldh1a7Neu
Gene:	Ldha  Location: Chr7:46491698-46505051 bp, + strand  Genetic Position: Chr7, 30.6 cM
Alliance:	Ldhaa-m7Neu page

Strain of Origin:

(102/El x C3H/El)F1

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: ENU-mutagenesis resulted in a transition at codon 194 (GAC to GCC) that caused an amino acid substitution of alanine for aspartic acid at position 194 (D194A). Enzyme activity is reduced to 63% of wild-type in heterozygotes and 24% of wild-type in ho0mozygotes. (J:45877)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ldha Mutation:	34 strains or lines available

Original:	J:15477 Charles DJ, et al., Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice. Mutat Res. 1987 Jan;176(1):81-91
All:	4 reference(s)