Slc4a7<Gt(RRL021)Byg> Gene trapped Allele Detail MGI Mouse (MGI:3775809)

Slc4a7^{Gt(RRL021)Byg}
Gene trapped Allele Detail

Summary

Symbol:	Slc4a7^{Gt(RRL021)Byg}
Name:	solute carrier family 4, sodium bicarbonate cotransporter, member 7; gene trap RRL021, BayGenomics
MGI ID:	MGI:3775809
Synonyms:	NBCn1^LacZ
Gene:	Slc4a7 Location: Chr14:7669819-7766808 bp, - strand Genetic Position: Chr14, 7.08 cM
Alliance:	Slc4a7^{Gt(RRL021)Byg} page

Mutation
origin

Mutant Cell Line:	RRL021
Germline Transmission:	Earliest citation of germline transmission: J:132199
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap

Mutation details: The gene trap vector was inserted between exons 3 and 4. Transcript levels are reduced 54% and protein levels 72% in homozygous mice. This is a hypomorphic allele. (J:132199)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Slc4a7 Mutation:	76 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

Original:	J:132199 Boedtkjer E, et al., Antibody-independent localization of the electroneutral Na+-HCO3- cotransporter NBCn1 (slc4a7) in mice. Am J Physiol Cell Physiol. 2008 Feb;294(2):C591-603
All:	2 reference(s)

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