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Tnnc1tm1e(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Tnnc1tm1e(KOMP)Wtsi
Name: troponin C, cardiac/slow skeletal; targeted mutation 1e, Wellcome Trust Sanger Institute
MGI ID: MGI:4362967
Gene: Tnnc1  Location: Chr14:30930274-30933671 bp, + strand  Genetic Position: Chr14, 19.09 cM
IMPC: Tnnc1 gene page
Mutation
origin
Mutant Cell Lines:  EPD0207_3_A07, EPD0207_3_B08, EPD0207_3_C05, EPD0207_3_E06, EPD0207_3_F05, EPD0207_3_F07, EPD0207_3_G06, EPD0207_3_G07, EPD0207_3_G08, EPD0207_4_B11
Germline Transmission:  Unknown
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 30930999 of Chromosome 14 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Tnnc1 Mutation:  11 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory