Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ifnlr1tm1Palu
Name:	interferon lambda receptor 1; targeted mutation 1, Soren R Paludan
MGI ID:	MGI:3775762
Synonyms:	IL-28RA-
Gene:	Ifnlr1  Location: Chr4:135413598-135435492 bp, + strand  Genetic Position: Chr4, 67.94 cM
Alliance:	Ifnlr1tm1Palu page

Germline Transmission:	Earliest citation of germline transmission: J:131989
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region including the 7 coding exons, 6 introns, and the first 219-bp of 3' untranslated region of the mouse Il28ra gene was replaced with an IRES-LacZ/MC1-Neo cassette by homologous recombination in ES cells. The real-time RT-PCR confirmed absence of expression. (J:131989)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ifnlr1 Mutation:	36 strains or lines available

Original:	J:131989 Ank N, et al., An important role for type III Interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J Immunol. 2008 Feb 15;180(4):2474-85
All:	36 reference(s)