Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Phb2tm1.1Tlan
Name:	prohibitin 2; targeted mutation 1.1, Thomas Langer
MGI ID:	MGI:3775183
Gene:	Phb2  Location: Chr6:124689299-124693913 bp, + strand  Genetic Position: Chr6, 59.17 cM
Alliance:	Phb2tm1.1Tlan page

Germline Transmission:	Earliest citation of germline transmission: J:131699
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 3 and 4 were removed by germ-line cre-mediated recombination. The ability of this allele to function as a null allele was confirmed by western blot analysis on total lysates of cells carrying the floxed allele and transduced with cre, in which case no protein products were detected. (J:131699)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phb2 Mutation:	22 strains or lines available

Original:	J:131699 Merkwirth C, et al., Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria. Genes Dev. 2008 Feb 15;22(4):476-88
All:	1 reference(s)