Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Uck1tm2a(KOMP)Wtsi
Name:	uridine-cytidine kinase 1; targeted mutation 2a, Wellcome Trust Sanger Institute
MGI ID:	MGI:4362314
Gene:	Uck1  Location: Chr2:32145014-32150117 bp, - strand  Genetic Position: Chr2, 22.09 cM
Alliance:	Uck1tm2a(KOMP)Wtsi page
IMPC:	Uck1 gene page

Mutant Cell Lines:	EPD0048_1_A02, EPD0048_1_B03, EPD0048_1_C01, EPD0048_1_C02, EPD0048_1_C03, EPD0048_1_D02, EPD0048_1_D03, EPD0048_1_E01, EPD0048_1_E02, EPD0048_1_E03, EPD0048_1_F01, EPD0048_1_F02, EPD0048_1_F03, EPD0048_1_G02, EPD0048_1_H02
Germline Transmission:	Earliest citation of germline transmission: J:204812
Parent Cell Line:	JM8.F6 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_gt1   Mutation details: The L1L2_gt1 cassette was inserted at position 32147881 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 32149134. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Uck1 Mutation:	33 strains or lines available

Original:	J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:	3 reference(s)