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Targeted Allele Detail
Symbol: Elp1tm1a(KOMP)Wtsi
Name: elongator complex protein 1; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4362242
Gene: Elp1  Location: Chr4:56749680-56802331 bp, - strand  Genetic Position: Chr4, 31.66 cM
Mutant Cell Lines:  EPD0033_2_A09, EPD0033_2_A10, EPD0033_2_B09, EPD0033_2_B10, EPD0033_2_C09, EPD0033_2_C10, EPD0033_2_D09, EPD0033_2_D10, EPD0033_2_E10, EPD0033_2_F09, EPD0033_2_F10, EPD0033_2_G10, EPD0033_2_H09, EPD0033_2_H10
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt0
Mutation detailsThe L1L2_gt0 cassette was inserted at position 56797052 of Chromosome 4 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 56796283. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
Schematic for the Elp1tm1a(KOMP)Wtsi and Elp1tm1c(KOMP)Wtsi alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 2 lines available
Carrying any Elp1 Mutation:  6 strains or lines available
Cell line EPD0033_2_A09 was successfully used to make chimeric mice. Germline transmission was accomplished by the IKMC (project 25621). J:202989
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory