Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Wnk4tm2Suc
Name:	WNK lysine deficient protein kinase 4; targeted mutation 2, Shinichi Uchida
MGI ID:	MGI:4360552
Gene:	Wnk4  Location: Chr11:101151393-101168235 bp, + strand  Genetic Position: Chr11, 64.51 cM
Alliance:	Wnk4tm2Suc page

Germline Transmission:	Earliest citation of germline transmission: J:152915
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A splice acceptor and floxed neo cassette was inserted upstream of exon 7 and an additional loxP site was inserted downstream of exon 7. (J:152915)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnk4 Mutation:	56 strains or lines available

Original:	J:152915 Ohta A, et al., Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet. 2009 Oct 15;18(20):3978-86
All:	1 reference(s)