Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prom1tm1.1(DTA)Toko
Name:	prominin 1; targeted mutation 1.1, Toru Kondo
MGI ID:	MGI:4360366
Synonyms:	Prom1lacZ,DTA, Prom1tm1Toko
Gene:	Prom1  Location: Chr5:44150962-44259374 bp, - strand  Genetic Position: Chr5, 23.97 cM
Alliance:	Prom1tm1.1(DTA)Toko page

Germline Transmission:	Earliest citation of germline transmission: J:152390
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced with a floxed lacZ gene with a polyadenylation sequence, diphtheria toxin A (DTA) gene, and frt flanked neo cassette. Germ-line flp-mediated recombination removed the neo cassette leaving the floxed lacZ-polyadenylation sequence upstream of the DTA gene. Cre mediated recombination is necessary to achieve expression of the DTA gene. (J:152390)

Generation of the Prom1tm1.1(DTA)Toko allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prom1 Mutation:	75 strains or lines available

Original:	J:152390 Nishide K, et al., Glioblastoma formation from cell population depleted of Prominin1-expressing cells. PLoS One. 2009;4(8):e6869
All:	3 reference(s)