Notch2<Gt(betageo)1Byg> Gene trapped Allele Detail MGI Mouse (MGI:4360085)

Notch2^{Gt(betageo)1Byg}
Gene trapped Allele Detail

Summary

Symbol:	Notch2^{Gt(betageo)1Byg}
Name:	notch 2; gene trap 1, BayGenomics
MGI ID:	MGI:4360085
Synonyms:	Notch2^lacZ
Gene:	Notch2 Location: Chr3:97920854-98057683 bp, + strand Genetic Position: Chr3, 42.42 cM
Alliance:	Notch2^{Gt(betageo)1Byg} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:146621
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Gene trapped (Null/knockout, Reporter)
Mutation:		Insertion of gene trap vector
		Mutation details: A beto-geo construct inserted into the locus creating a null allele. Reporter gene expression was detected in subsets of B cells. (J:146621)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Notch2 Mutation:	97 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

Original:	J:146621 Tan JB, et al., Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches. Immunity. 2009 Feb;30(2):254-63
All:	2 reference(s)

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