About   Help   FAQ
Grk5tm2Rjl
Targeted Allele Detail
Summary
Symbol: Grk5tm2Rjl
Name: G protein-coupled receptor kinase 5; targeted mutation 2, Robert J Lefkowitz
MGI ID: MGI:4359730
Synonyms: GRK5 flox
Gene: Grk5  Location: Chr19:60878187-61084406 bp, + strand  Genetic Position: Chr19, 56.52 cM
Alliance: Grk5tm2Rjl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152746
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 7 and 8 were flanked by loxP sites and a neomycin resistance cassette followed by a loxP site was placed in intron 8. Transient transfection with cre recombinase excised the neomycin resistance cassette, leaving exons 7 and 8 floxed. (J:59179, J:152746)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grk5 Mutation:  43 strains or lines available
References
Original:  J:152746 Lefkowitz RJ, Generation of a Grk5 floxed allele. MGI Direct Data Submission. 2009;
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory