Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ryr2tm1.1Wex
Name:	ryanodine receptor 2, cardiac; targeted mutation 1.1, Xander Wehrens
MGI ID:	MGI:4359589
Synonyms:	Ryr2S2814A
Gene:	Ryr2  Location: Chr13:11567988-12121831 bp, - strand  Genetic Position: Chr13, 4.38 cM, cytoband A1-A2
Alliance:	Ryr2tm1.1Wex page

Germline Transmission:	Earliest citation of germline transmission: J:152544
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Exon 56 was replaced with one containing nucleotide substitutions that result in the amino acid substitution of alanine for serine at position 2814 (S2814A). The modified exon was followed by a floxed neo cassette that was removed by subsequent germ line, cre mediated recombination. (J:152544)

Generation of the Ryr2tm1.1Wex allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ryr2 Mutation:	325 strains or lines available

Original:	J:152544 Chelu MG, et al., Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul;119(7):1940-51
All:	18 reference(s)