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Targeted Allele Detail
Symbol: Pdx1tm1.1Stof
Name: pancreatic and duodenal homeobox 1; targeted mutation 1.1, Doris Stoffers
MGI ID: MGI:4359453
Synonyms: Pdx1deltaC
Gene: Pdx1  Location: Chr5:147270131-147275149 bp, + strand  Genetic Position: Chr5, 86.84 cM
Pancreatic hypoplasia in Pdx1tm1Cvw/Pdx1tm1.1Stof mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:152582
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 2 was replaced with one in which nucleotide substitutions result in the amino acid substitution of serine with a STOP codon at position 210 (S210X). The modified exon was followed by a floxed neo cassette that was removed via germ line, cre mediated recombination. The predicted product lacks 74 amino acids of the C terminus. A 75% reduction in full-length expression was confirmed by western blot analysis on E13.5 pancreatic extracts. (J:152582)
Generation of the Pdx1tm1.1Stof allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdx1 Mutation:  22 strains or lines available
Original:  J:152582 Oliver-Krasinski JM, et al., The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest. 2009 Jul;119(7):1888-98
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory