Stat1tm1Tdec
Targeted Allele Detail
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| Symbol: |
Stat1tm1Tdec |
| Name: |
signal transducer and activator of transcription 1; targeted mutation 1, Thomas Decker |
| MGI ID: |
MGI:3774319 |
| Synonyms: |
Stat1S272A, Stat1tm1(S727A) |
| Gene: |
Stat1 Location: Chr1:52158599-52201024 bp, + strand Genetic Position: Chr1, 26.81 cM
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| Alliance: |
Stat1tm1Tdec page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:130622
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Not Applicable) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Exon 22 and 23a were replaced with a segment containing exon 22, a floxed neo cassette and exon 23 containing a nucleotide substitution that results in an amino acid substitution of an alanine for a serine at position 727 (S727A), a site within the transactivation domain. The neo cassette was removed by germ-line, cre-mediated recombination. Protein expression and the absence of phosphorylation was confirmed by western blot analysis.
(J:130622)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Stat1 Mutation: |
72 strains or lines available
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| Original: |
J:130622 Varinou L, et al., Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity. Immunity. 2003 Dec;19(6):793-802 |
| All: |
6 reference(s) |
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Analysis Tools
