Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mitftm1.2Arnh
Name:	melanogenesis associated transcription factor; targeted mutation 1.2, Heinz Arnheiter
MGI ID:	MGI:3774164
Synonyms:	Mitf S73A1, Mitf S73A2, Mitf S73A3
Gene:	Mitf  Location: Chr6:97784013-97998310 bp, + strand  Genetic Position: Chr6, 45.05 cM
Alliance:	Mitftm1.2Arnh page

Germline Transmission:	Earliest citation of germline transmission: J:130168
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mutation details: Breeding of Mitftm1.1Arnh mice led to several instances of phenotypic reversion. Genomic analysis revealed in that all cases the intragenic duplication event of 85,222 bp of wild-type gene sequence was lost, leaving in place the targeted mutation of amino acid 73 from serine to alanine (S73A) in exon 2B. (J:130168)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mitf Mutation:	72 strains or lines available

Original:	J:130168 Bismuth K, et al., An unstable targeted allele of the mouse mitf gene with a high somatic and germline reversion rate. Genetics. 2008 Jan;178(1):259-72
All:	1 reference(s)