Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Alx4m1Btlr
Name:	aristaless-like homeobox 4; mutation 1, Bruce Beutler
MGI ID:	MGI:3774135
Synonyms:	goofy
Gene:	Alx4  Location: Chr2:93472779-93511686 bp, + strand  Genetic Position: Chr2, 51.62 cM
Alliance:	Alx4m1Btlr page

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: The goofy mutation corresponds to an A to G transition at nucleotide position 1010 (Genbank Accession NM_007442), in exon 4 of 5 total exons, that results in replacement of histidine by arginine at amino acid position 272 of the protein (H272R). Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Alx4 Mutation:	20 strains or lines available

Original:	J:132742 Du X, et al., Goofy, a mouse Alx4 mutant with anomalies of craniofacial and digit development and hair growth. MGI Direct Data Submission. 2008;
All:	1 reference(s)