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Rfktm1.1Jcbr
Targeted Allele Detail
Summary
Symbol: Rfktm1.1Jcbr
Name: riboflavin kinase; targeted mutation 1.1, Jens C Bruning
MGI ID: MGI:4356069
Synonyms: Rfkflox
Gene: Rfk  Location: Chr19:17371407-17378713 bp, + strand  Genetic Position: Chr19, 12.82 cM, cytoband B
Alliance: Rfktm1.1Jcbr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151999
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA frt-flanked neomycin cassette and an upstream loxP site was inserted upstream of exon 1. A second loxP site was inserted downstream of exon 2 at nucleotide position 1080. Founder mice were generated from homologously targeted clones and then crossed with Flp-deleter to remove the neomycin cassette and leave exons 1 and 2 floxed. Correct targeting was confirmed by Southern blotting. (J:151999)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rfk Mutation:  19 strains or lines available
References
Original:  J:151999 Yazdanpanah B, et al., Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature. 2009 Aug 27;460(7259):1159-63
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory