Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Etv6tm1(RUNX1)Haho
Name:	ets variant 6; targeted mutation 1, Hanno Hock
MGI ID:	MGI:4355899
Synonyms:	TEL-AML1
Gene:	Etv6  Location: Chr6:134012663-134247121 bp, + strand  Genetic Position: Chr6, 64.58 cM, cytoband G2
Alliance:	Etv6tm1(RUNX1)Haho page

Germline Transmission:	Earliest citation of germline transmission: J:151639
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Conditional ready, Humanized sequence, No functional change) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 6 and 7 were replaced with a floxed neo, floxed STOP, and human RUNX1 coding region. When the floxed neo and STOP cassette are removed by cre-mediated recombination, a fusion product of mouse Etv6 and human RUNX1 (or TEL-AML1) was created. (J:151639)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Etv6 Mutation:	142 strains or lines available

Original:	J:151639 Schindler JW, et al., TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. Cell Stem Cell. 2009 Jul 2;5(1):43-53
All:	2 reference(s)