Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Trp63tm1Elrf
Name:	transformation related protein 63; targeted mutation 1, Elsa R Flores
MGI ID:	MGI:4355527
Synonyms:	TAp63fl
Gene:	Trp63  Location: Chr16:25502513-25710838 bp, + strand  Genetic Position: Chr16, 17.37 cM
Alliance:	Trp63tm1Elrf page

Germline Transmission:	Earliest citation of germline transmission: J:151638
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Allele Type:    Targeted (Conditional ready, Modified isoform(s), No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and loxP site were inserted into intron 2. This creates a conditional-ready allele with exon 2, used for the TA isoforms, floxed. (J:151638)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trp63 Mutation:	60 strains or lines available

Original:	J:151638 Su X, et al., TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell. 2009 Jul 2;5(1):64-75
All:	4 reference(s)