Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 8, Ralf Kuhn
MGI ID:	MGI:4353628
Synonyms:	shCRHR1
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn page

Germline Transmission:	Earliest citation of germline transmission: J:151155
Parent Cell Line:	IDG3.2 (ES Cell)
Strain of Origin:	(C57BL/6J x 129S6/SvEvTac)F1

Allele Type:    Targeted Mutation:    Insertion   Gt(ROSA)26Sortm8(RNAi:Crhr1)Rkuhn involves 1 genes/genome features (Crhr1) View all   Mutation details: Using RMCE, an inserted hygro cassette was replaced with a neo cassette and a short hairpin RNA driven by the human U6 promoter that targets Crhr1. Expression of the shRNA results in an 80% reduction in endogenous Crhr1 transcript levels compared to in wild-type mice. (J:151155)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:151155 Delic S, et al., Genetic mouse models for behavioral analysis through transgenic RNAi technology. Genes Brain Behav. 2008 Oct;7(7):821-30
All:	1 reference(s)