Summary | Transgene origin | Transgene description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(CTSG-RARA/PML)2544Ley
Name:	transgene insertion 2544, Timothy Ley
MGI ID:	MGI:4353271
Transgene:	Tg(CTSG-RARA/PML)2544Ley  Location: unknown
Alliance:	Tg(CTSG-RARA/PML)2544Ley page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Mutation details: The functional cDNA coding sequence is derived from the breakpoint cluster region 3 (bcr-3) isoform transcript of the RARA/PML fusion gene resulting from the characteristic t(15;17)(q22;q11.2-q12) translocation associated with ~90% of human cases of acute promyelocytic leukemia (APML). The bcr-3 isoform of the chimeric gene joins exon 2 of the retinoic acid receptor alpha (RARA) gene in-frame to PML exons 4-8. Expression is targeted specifically to early myeloid-lineage cells by the promoter and 5' regulatory elements of the human cathepsin G gene. Two lines were created (2544 and 2683). (J:59080)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Tg(CTSG-RARA/PML)2544Ley

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:59080 Pollock JL, et al., A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15103-8
All:	1 reference(s)