Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Myctm4.1Fwa
Name:	myelocytomatosis oncogene; targeted mutation 4.1, Frederick W Alt
MGI ID:	MGI:4352684
Synonyms:	c-Myc25Isce
Gene:	Myc  Location: Chr15:61857240-61862223 bp, + strand  Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
Alliance:	Myctm4.1Fwa page

Germline Transmission:	Earliest citation of germline transmission: J:150339
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Not Applicable) Mutation:    Insertion   Mutation details: A cassette containing 25 tandem I-SceI target sites (S. cerevisiae) endonuclease recognition site (TAGGGATAACAGGGTAAT) was inserted into intron 1 of the gene. A floxed neomycin cassette was included upstream of the I-SceI cassette and was subsequently removed by transient expression of cre recombinase. Correct targeting was confirmed by Southern blotting. (J:150339)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myc Mutation:	42 strains or lines available

Original:	J:150339 Wang JH, et al., Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 2009 Jul 9;460(7252):231-6
All:	6 reference(s)